Glomangiopericytoma of the Infraorbital Region
Published in Head and Neck Pathology, 2025
Shen-Han Lee 1,2, Mohamd Azizul Fitri Khalid 3, Amirozi Ahmad 3, Noorjehan Omar 4 , Ramiza Ramza Ramli 1,2,*
1 Department of Otorhinolaryngology, Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
2 Hospital Pakar Universiti Sains Malaysia, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia
3 KPJ Penang Specialist Hospital, Bukit Mertajam, Pulau Pinang, Malaysia
4 Lablink Medical Laboratory, Kuala Lumpur, Malaysia
* Corresponding author: ramizaramza@usm.my
Background: Glomangiopericytomas are rare spindle cell neoplasms that typically arise within the sinonasal tract and exhibit borderline to low malignant potential. While unusual, occurrences of this tumor in other regions of the head and neck have been reported, such as the deep neck spaces, larynx, tongue, and middle ear.
Case presentation: A 44-year-old male presented with a one-year history of left infraorbital swelling, enlarging over two months and occasionally pulsating with discomfort. Cross-sectional imaging revealed a 1.5 cm x 0.8 cm x 1.7 cm homogeneously-enhancing mass in the left medial infraorbital region eroding the adjacent maxillary sinus wall, suggestive of an infraorbital nerve schwannoma or hemangioma. The tumor was excised via a lateral rhinotomy approach with anterior maxillectomy. The final pathological diagnosis was a glomangiopericytoma.
Conclusion: Although typically localized to the sinonasal tract, glomangiopericytomas may arise in unusual head and neck locations such as the infraorbital region. It is important to distinguish these tumors from related mesenchymal tumors such as solitary fibrous tumors and myopericytomas due to differences in their biology and malignant potential.
Keywords: Glomangiopericytoma; Infraorbital tumor; Mesenchymal tumor; Spindle cell tumor.
DOI: 10.1007/s12105-025-01810-1
© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Recommended citation: Lee SH, Khalid MAF, Ahmad A, Omar N, Ramli RR. (2025). "Glomangiopericytoma of the Infraorbital Region." Head and Neck Pathology. 19(1):101.
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